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KMID : 0882420090770050620
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Korean Journal of Medicine
2009 Volume.77 No. 5 p.620 ~ p.624
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A case of type 3 hyperlipoproteinemia associated with generalized tuberoeruptive xanthomas
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Kim Eun-Young
Seo Ki-Woo
Kim Jung-Eun
Cho Eun-Jung
Lee Wang-Soo
Kim Chee-Jeong
Li Kap-Sok
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Abstract
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A 55-year-old female presented with extensive yellowish eruptive plaques over both elbows and the buttocks that she had first noticed 2 years earlier. Yellowish orange discoloration of her palmar creases was noted. Her serum cholesterol and triglyceride were markedly elevated. Lipoprotein electrophoresis showed a broad β band. On apolipoprotein E genotyping, the arginine at position 158 had been replaced by cysteine in both alleles (E2/E2). Under a diagnosis of type III hyperlipoproteinemia, combined atorvastatin and fenofibrate therapy for 2 months normalized the serum cholesterol and triglyceride levels.
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KEYWORD
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Type 3 hyperlipoproteinemia, Apolipoprotein E
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